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Human & Experimental Toxicology
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Effects of high-level exposure to lead on NK cell activity and T-lymphocyte functions in workers

Berran Yücesoy

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan

Aslihan Turhan

Department of Immunology, Faculty of Medicine, Gazi University, 06500, Besevler, Ankara

Saied Mirshahidi

Department of Immunology, Faculty of Medicine, Gazi University, 06500, Besevler, Ankara

Murat Üre

Social Security Society, Ankara Occupational Disease Hospital, 06530, Yenimahalle, Ankara, Turkey

Turgut Imir

Department of Immunology, Faculty of Medicine, Gazi University, 06500, Besevler, Ankara

Asuman Karakaya

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan

1 NK and T cell functions were measured in peripheral blood lymphocytes of workers occupationally exposed to lead.

2 No differences were found in these functions even in those workers with higher levels of blood and urine lead and urinary {delta}-ALA than the currently accepted biological limit values as compared to controls.

3 We conclude that high chronic exposure to lead is not associated with an impairment or either T- or NK cell functions in man.

Key Words: lead • T-lymphocyte proliferation • natural killer cell activity

Human & Experimental Toxicology, Vol. 16, No. 6, 311-314 (1997)
DOI: 10.1177/096032719701600603
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