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In utero and lactational exposure of carbofuran to rats: Effect on testes and sperm

Industrial Toxicology Research Centre, Post Box No. 80, MG Marg, Lucknow-226 001, India

R. Shankar

Industrial Toxicology Research Centre, Post Box No. 80, MG Marg, Lucknow-226 001, India

SP Srivastava

Industrial Toxicology Research Centre, Post Box No. 80, MG Marg, Lucknow-226 001, India

1 Male offspring of adult females treated with 0.2 or 0.4 mg/kg during either the whole of pregnancy or the whole of the lactation period did not induce general ised toxic effects.

2 A significant alteration in enzymatic activities i.e. SDH (decreased), LDH and Y-GT (increased) were observed in testes only at 0.4 mg/kg.

3 A decrease in sperm motility, sperm count along with increase in percent abnormal sperm was observed at 0.4 mg/kg dose level.

4 Histopathological examination revealed loss of sper mato-genesis, degenerative changes in Sertoli cells which are well supported with biochemical studies indicating that carbofuran interferes with the matura tion process of testis.

5 No such effects were observed at 0.2 mg/kg.

6 The testicular and spermatotoxic effects observed in rats given in utero or lactational exposure may be due to transfer of carbofuran or its metabolites through placenta or mothers milk.

Key Words: carbofuran • rat • sperm • testes

Human & Experimental Toxicology, Vol. 16, No. 5, 267-272 (1997)
DOI: 10.1177/096032719701600506


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