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Pro- and anti-oxidant parameters in rat liver after short term exposure to hexachlorobenzene

Departamento de Análises Clinícas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Natal (RN), Brasil

F. Fanini

Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (Brasil)

SC Davino

Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (Brasil)

AE Aznar

Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (Brasil)

OR Koch

Facultad de Medicina, Universidad de Buenos Aires

SB de M Barros

Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (Brasil)

The association between an in vivo oxidative stress condition of the liver and hepatic porphyria during HCB intoxication is postulated. After 30 days of treatment, HCB (25 mg/kg b.w.) promotes an induction of microsomal cytochrome P450 system, increase in microsomal super oxide anion generation accompanied by increased levels of liver lipid peroxidation, as measured by the production of thiobarbituric acid reactants and by spontaneous visible chemiluminescence. Concomitantly, liver antiox idant defenses are slightly modified, with decreased activity of glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase contributing to an oxidative stress condition of the liver. These liver biochemical alterations are closely related to increased levels of urinary coproporphyrin, plasma AST and ALT activities and to the onset of liver morphological lesions

Key Words: oxidative stress • porphyria • liver • hexachlorobenzene

Human & Experimental Toxicology, Vol. 16, No. 5, 257-261 (1997)
DOI: 10.1177/096032719701600504


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