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Human & Experimental Toxicology
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Reactive oxygen species involvement in ricin-induced thyroid toxicity in rat

Geeta R Sadani

Free Radical Biochemistry Section, Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay-400 012

Chitralekha S Soman

Department of Pathology, Tata Memorial Hospital, Parel, Bombay-400 012, India

Kedar K Deodhar

Department of Pathology, Tata Memorial Hospital, Parel, Bombay-400 012, India

Ganeshsunder D Nadkarni

Free Radical Biochemistry Section, Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Bombay-400 012

1 Ricin is known to have diverse effects on the cells of different organs like liver, kidney, pancreas, intestines and parathyroid.

2 Acute decrease in serum thyroid hormone levels 24 h after ricin administration (1.5 µg/100 g) led us to suspect the toxic action of ricin on the thyroid.

3 We monitored the lipid peroxidation (LP) and anti oxidant status of the thyroid tissue to determine the role, if any, played by reactive oxygen species (ROS) in this pathology.

4 An increase of 39% in LP and 47% in superoxide dismutase, along with a 8.5% decrease in catalase

points to the imbalance in the antioxidant defence involving hydrogen peroxide and its univalent reduc tion product, the hydroxyl radical.

5 Thyroid histopathology shows destruction of thyroid follicles and necrosis, which may be due to ROS and may partly explain the 50% reduction in circulating thyroid hormones seen after ricin administration.

Key Words: reactive oxygen species • antioxidants • ricin • thyroid • lipid peroxidation • free radicals

Human & Experimental Toxicology, Vol. 16, No. 5, 254-256 (1997)
DOI: 10.1177/096032719701600503
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