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Human & Experimental Toxicology
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Oral N-acetylcysteine protects against perfluoroisobutene toxicity in rats

Alison F Lailey

Medical Countermeasures, Chemical and Biological Defence, Defence Evaluation and Research Agency (DERA), Porton Down, Salisbury, Wilts, SP4 0JQ, UK

1 Perfluoroisobutene, a pyrolysis product of polytetra fluoroethene may cause pulmonary oedema and death when inhaled. Oral N-acetylcysteine has shown protection against inhalation of perfluoroisobutene and in this study we have tried to elucidate the mechanism by which protection is mediated.

2 Protection against the lethal effects of inhaled per fluoroisobutene has been shown when N-acetylcys teine has been orally administered 4, 6 or 8 h before gas exposure.

3 Plasma levels of cysteine, glutathione and N-acetylcys teine were increased for up to 7 h following oral administration of Nac.

4 N-acetylcysteine was not detected in the bronchio alveolar lavage fluid following oral administration.

5 Duration of protection in vivo has been related to the duration of increased thiol levels in the plasma.

Key Words: perfluoroisobutene • N-acetylcysteine • cysteine • glu tathione • protection

Human & Experimental Toxicology, Vol. 16, No. 4, 212-216 (1997)
DOI: 10.1177/096032719701600410
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