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Human & Experimental Toxicology
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No linkage of the cytochrome P-450IIE1 (CYP2E1) C1/C2 polymorphism to schizophrenia

K. Iwahashi

Department of Neuropsychiatry, Kagawa Medical School

K. Nakamura

Department of Neuropsychiatry, Kagawa Medical School

A. Furukawa

Department of Biochemistry, Kagawa Medical School, Kita-gun, Miki-cho, Kagawa 761-07, Japan

E. Okuyama

Department of Biochemistry, Kagawa Medical School, Kita-gun, Miki-cho, Kagawa 761-07, Japan

R. Miyatake

Department of Neuropsychiatry, Kagawa Medical School

Y. Ichikawa

Department of Biochemistry, Kagawa Medical School, Kita-gun, Miki-cho, Kagawa 761-07, Japan

H. Suwaki

Department of Neuropsychiatry, Kagawa Medical School

We investigated, using PCR-SSCP analysis, the relation ship between schizophrenia and the polymorphism of d- benzphetamine N-demethylase (cytochrome P-450j or CYP2E1), which metabolizes psychotropic substances such as d-benzphetamine and alcohols. Among 41 patients with schizophrenia, no statistically significant change in the frequency of the mutant (C2) allele relative to in controls was found, and no novel structural mutation in the CYP2E1 gene, which would be expected to alter the CYP2E1 protein, was found. This could be explained by no linkage of the CYP2E1 gene (mutations in the exon 1- 9, and C1/C2 polymorphism) to schizophrenia.

Key Words: schizophrenia • CYP2E1 • genotype • SSCP • mutation

Human & Experimental Toxicology, Vol. 16, No. 4, 208-211 (1997)
DOI: 10.1177/096032719701600409
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