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Human & Experimental Toxicology
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Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture

M. Jurima-Romet

Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario, Canada

S. Neigh

Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario, Canada

WL Casley

Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario, Canada

1 Rat hepatocytes cultured on a Matrigel matrix were exposed for 48 h to all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid or fenreti nide.

2 Cytochrome P450 3A (CYP3A) RNA levels were increased by approximately eightfold in hepatocytes treated with the retinoids compared to control cultures.

3 CYP1A1 and CYP1A2 RNA levels were only slightly affected or unaffected by the retinoids.

4 The induction of CYP3A by these therapeutically- useful retinoids suggests that they may share a common mechanism for accelerated drug catabolism and acquired clinical resistance.

Key Words: Cytochrome P450 • retinoids • hepatocytes • rat

Human & Experimental Toxicology, Vol. 16, No. 4, 198-203 (1997)
DOI: 10.1177/096032719701600407
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