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Dosimetry and pathology of 237Np in female rats

Forschungszentrum Karlsruhe, Institut für Toxikologie, Postfach 3640, 76021 Karlsruhe

R. Wirth

Forschungszentrum Karlsruhe, Institut für Toxikologie, Postfach 3640, 76021 Karlsruhe

A. Luz

Forschungszentrum für Umwelt and Gesundheit, Institut für Pathologie, Postfach 1129, 85758 Oberschleißheim Germany

E. Schäffer

Forschungszentrum Karlsruhe, Institut für Toxikologie, Postfach 3640, 76021 Karlsruhe

V. Volf

Forschungszentrum Karlsruhe, Institut für Toxikologie, Postfach 3640, 76021 Karlsruhe

Female Sprague-Dawley rats, 10-12-week old and weigh ing about 240 g, were injected intravenously with ²³⁷Np nitrate. In the toxicological study 77 rats served as controls and 28 rats per group received single doses of 5.2 and 26 kBq, respectively, per kg body weight. In addition, 12 rats of each injection level, sacrificed at defined points in time, were used for dosimetric studies. During the whole life-span the body weight and ²³⁷Np whole body-content of each animal were recorded. After death a detailed pathological examination was made of each animal in the cronical study. One day after injection 48% of the injected activity was in the skeleton, 9.3% in the liver, 3% in the kidneys and 4.4% in the rest of the organs. Whereas in all organs the activity decreased very fast, the half-life in the skeleton was about 1400 days. The bodyweights were comparable in the three groups, but the life span decreased from 800 days (control group) to 644 days after injection (26 kBq kg ^-1 body weight group). The main lesions in the female rats were mammary tumors (73%) and pituitary gland tumors (52%). With increasing activity the incidence of pituary gland tumors decreased and that of osteosarco mas increased from 1.3% (control group) to 32% (26 kBq kg^-1 body weight group), whereas the remaining lesions showed no influence on the activity.

Key Words: Neptunium-237 • rats • dosimetry • survival analysis • pathology

Human & Experimental Toxicology, Vol. 16, No. 2, 89-100 (1997)
DOI: 10.1177/096032719701600204


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