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The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

C. Charlton

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

Gail E de Blaquière

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

Elaine Mutch

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

SS Kelly

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

PG Blain

Department of Environmental and Occupational Medicine, The Medical School, Newcastle University NE2 4HH, UK

1 Multiple low doses of the direct acting organopho sphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and ecothiopate than for mipafox.

2 Ecothiopate did not inhibit brain acetylcholinesterase but there was a small increase in activity.

3 Mipafox also had a cumulative inhibitory effect on brain neuropathy target esterase.

4 These results have particular implication for the use of multiple low doses of organophosphates occupation- ally by man.

Key Words: organophosphates • multiple exposure • brain • dia phragm • acetylcholinesterases

Human & Experimental Toxicology, Vol. 16, No. 2, 67-71 (1997)
DOI: 10.1177/096032719701600201


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