This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rio, B. Articles by Parent-Massin, D. Search for Related Content PubMed PubMed Citation Articles by Rio, B. Articles by Parent-Massin, D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB T-2 TOXIN Social Bookmarking                         What's this?

In vitro toxicity of trichothecenes on human erythroblastic progenitors

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané France

S. Lautraite

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané France

D. Parent-Massin

Laboratoire de Microbiologie et Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technopôle Brest-Iroise, 29280 Plouzané France

Trichothecenes are mycotoxins produced by various species of fungi which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and potent trichothe cenes. Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicoses. Trichothecenes are known to induce haematologic dis orders such as neutropenia, thrombopenia, and aplastic anemia in human and animals.

The aim of our investigations is to explore the effects of trichothecenes on the haematopoietic progenitors. The four trichothecenes previously demonstrated to be strongly cytotoxic for human CFU-GM have been tested on human BFU-E. For this purpose, a culture model of human erythroblastic progenitors (BFU-E) optimized for toxicological studies was used to determine the effects of T-2, HT-2, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) on red blood cell precursor proliferation and differentiation. Results showed that human BFU-E are as sensitive to trichothecenes as human CFU-GM, except for DON, in the range of concentrations tested. Differentiation of erythroblastic progenitors could be perturbed by these mycotoxins. Human erythroblastic progenitors are also a target of trichothecenes.

Key Words: food toxicology • trichothecenes • haematotoxicity • erythroblastic progenitors • mycotoxins

Human & Experimental Toxicology, Vol. 16, No. 11, 673-679 (1997)
DOI: 10.1177/096032719701601108


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R Froquet, G Le Drean, and D Parent-Massin Effect of Ochratoxin a on human haematopoietic progenitors proliferation and differentiation: an in vitro study Human and Experimental Toxicology, July 1, 2003; 22(7): 393 - 400. [Abstract] [PDF]

				R Froquet, Y Sibiril, and D Parent-Massin Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK) Human and Experimental Toxicology, February 1, 2001; 20(2): 84 - 89. [Abstract] [PDF]