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Compartmental transfer of mercury released from amalgam

Institute of Toxicology, GSF-National Research Center for Environment and Health

L. Kremers

Department of Restorative Dentistry and Periodontology, University of Munich, Goethestr. 70, D-80336-München

H. Willruth

Department of Restorative Dentistry and Periodontology, University of Munich, Goethestr. 70, D-80336-München

A. Mehl

Department of Restorative Dentistry and Periodontology, University of Munich, Goethestr. 70, D-80336-München

G. Welzl

Institute of Biomathematics and Biometry, GSF-National Research Center for Environment and Health, Neuherberg, D-85758-Oberschleissheim

FX Wack

Army Dentistry Unit 612/2, Fürst-Wrede-Kaserne, Ingolstädter Str. 240, D-80935-München, Germany

R. Hickel

Department of Restorative Dentistry and Periodontology, University of Munich, Goethestr. 70, D-80336-München

H. Greim

Institute of Toxicology, GSF-National Research Center for Environment and Health

The number of amalgam-covered surfaces and the occlusal area of the fillings, the concentrations of total mercury in plasma, erythrocytes and urine, the urinary excretion rate, and the absorbed daily doses estimated by two separate methods from intra-oral Hg emission were determined in 29 volunteers with a low amalgam load. The transfer ofHg from the fillings via the oral cavity and blood to urinary excretion was evaluated by multiple correla tions between these variables. In addition, the combina tion of variables most representative of the entire compartmental transfer of amalgam Hg was determined. Urinary excretion (1), Hg concentration in plasma (2) and absorbed dose (3) were most closely correlated to each other, followed by correlations with the variables of the fillings (4). Correlation coefficients were 0.75 for variables 1 vs 2 and 2 vs 3, and 0.49 for variables 3 vs 4. It was concluded that variables 1-3 best reflected the transfer of mercury from amalgam fillings throughout the organism and that they were relatively insensitive to dietary mercury. The determination of total mercury in plasma and of its urinary excretion rate appears, under practical aspects, most suitable for the investigation of Hg uptake from amalgam.

Key Words: amalgam • mercury transfer • plasma • urinary excretion • mercury dose

Human & Experimental Toxicology, Vol. 16, No. 11, 667-672 (1997)
DOI: 10.1177/096032719701601107


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