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Environmental exposure to polycyclic aromatic hydrocarbons in Czech Republic

Departement de médecine du travail et d'hygiène du milieu, Faculté de médecine, Université de Montréal, Montréal, Canada

Zdenek Fiala

Department of Hygiene and Preventive Medicine, Medical Faculty, Charles University, Hradec Kralové, Czech Republic

Dana Fialova

Departement of Physical Education, Pedagogical University, Hradec Kralové, Czech Republic

Vladimir Krajak

Regional Hygienic Station, Hradec Kralové, Czech Republic

Claude Viau

Departement de médecine du travail et d'hygiène du milieu, Faculté de médecine, Université de Montréal, Montréal, Canada

1 Objectives of this study were (1) to compare concentra tions of individual polycyclic aromatic hydrocarbons (PAH) in air of polluted and nonpolluted area of Czech Republic during winter and summer periods and (2) to verify if urinary 1-hydroxypyrene (1-OHP), as sup posed practical biological marker, permits the assess ment of spacial and temporal variations in environmental PAH exposure.

2 The study population consisted of three groups: (1) a group of 22 physical exercise students who regularly train outside, from the university situated in a polluted town, spending 14 days in winter and 14 days in summer in 'non-polluted' mountains; (2) a control group of 22 residents from the town and (3) a control group of 18 residents from the mountains.

3 The total PAH concentrations (sum of 13 individual PAH) were 19.3 and 104.6 ng/m³ in town and in mountains, respectively, during summer and 86.6 and 261 ng/m³ during winter.

4 Median 1-OHP levels ranged between 0.03 and 0.13 µmol/mol creatinine for controls and between 0.04 and 0.12 µmol/mol creatinine for students. No relationship was found between pyrene levels in air and group means of urinary 1-OHP. Our results show that other factors (probably PAH in food) contribute in masking air pollution influence on urinary 1-OHP levels in subjects non-occupationally exposed to PAH.

Key Words: human • environmental exposure • polycyclic aromatic hydrocarbons • biological monitoring

Human & Experimental Toxicology, Vol. 16, No. 10, 589-595 (1997)
DOI: 10.1177/096032719701601006


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