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Human & Experimental Toxicology
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Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats

J. Kassa

Purkyne Military Medical Academy, Hradec Králové, Czech Republic

J. Fusek

Purkyne Military Medical Academy, Hradec Králové, Czech Republic

1 The effect of pharmacological pretreatment (pyridos tigmine, benactyzine and trihexyphenidyle), desig nated Panpal, and antidotal treatment (the oxime HI- 6 plus benactyzine) in soman poisoning was investi gated in a rat model with on-line monitoring of respiratory and circulatory parameters.

2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activ ity in diaphragm and various brain parts.

3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acet ylcholinesterase activity in all brain parts studied.

4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreat ment or antidotal treatment alone.

5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman- poisoned rats without significant reactivation of brain acetylcholinesterase.

Key Words: soman • rat • Panpal • HI-6 • benactyzine • respiration • circulation

Human & Experimental Toxicology, Vol. 16, No. 10, 563-569 (1997)
DOI: 10.1177/096032719701601003
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