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In vitro drug adsorption to charcoal, silicas, acrylate copolymer and silicone oil with charcoal and with acrylate copolymer

Dow Corning, Health Environmental and RegulatoryAffairs, Barry, South Glamorgan and Department of Pharmacology, Therapeutics & Toxicology University of Wales College of Medicine, Llandough Hospital, Nr Penarth, South Glamorgan

A. Hale

Dow Corning, Health Environmental and RegulatoryAffairs, Barry, South Glamorgan and Department of Pharmacology, Therapeutics & Toxicology University of Wales College of Medicine, Llandough Hospital, Nr Penarth, South Glamorgan

DC Buss

Dow Corning, Health Environmental and RegulatoryAffairs, Barry, South Glamorgan and Department of Pharmacology, Therapeutics & Toxicology University of Wales College of Medicine, Llandough Hospital, Nr Penarth, South Glamorgan

PA Routledge

Dow Corning, Health Environmental and RegulatoryAffairs, Barry, South Glamorgan and Department of Pharmacology, Therapeutics & Toxicology University of Wales College of Medicine, Llandough Hospital, Nr Penarth, South Glamorgan

1 The relative binding constants of four drugs to charcoal, silicone oil silicas and acrylate copolymers was studied using an in-vitro binding technique.

2 The maximum adsorption capacity (K2) was chosen as a measure of the degree of binding and calculated by fitting to the Langmuir equation.

3 Charcoal alone was shown to be the most effective of the adsorbents chosen. The possible use of silicone oils as an adsorbent delivery vehicle in treatment of overdose is discussed.

Key Words: Adsorption • charcoal • silicone oil • acrylate copolymer

Human & Experimental Toxicology, Vol. 16, No. 1, 25-27 (1997)
DOI: 10.1177/0960327197016001051


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