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Human & Experimental Toxicology
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*Compound via MeSH
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*Biodefense and Bioterrorism
*Chemical Emergencies
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*BIS(2-CHLOROETHYL)SULFIDE
*CYSTEINE
*SODIUM BENZENETHIOLATE
*THIOPHENOL
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What's this?

The effect of sulphur mustard on glutathione levels in rat lung slices and the influence of treatment with arylthiols and cysteine esters

AM Langford

Toxicology Unit, Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle, NE2 4HH

MJ Hobbs

Medical Countermeasure (Biology), CBD, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK

DG Upshall

Medical Countermeasure (Biology), CBD, Porton Down, Salisbury, Wiltshire, SP4 OJQ, UK

PG Blain

Toxicology Unit, Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle, NE2 4HH

Faith M Williams

Toxicology Unit, Department of Environmental and Occupational Medicine, The Medical School, University of Newcastle upon Tyne, Newcastle, NE2 4HH

1 Sulphur mustard reacts directly with benzenethiols and cysteine esters in aqueous medium.

2 Benzenethiols diffuse into lung slices in short term culture.

3 Treatment of lung slices in short term culture with benzenethiols does not protect cellular glutathione from conjugation with sulphur mustard.

4 Following uptake of cysteine ester into lung slices cysteine is elevated but this does not protect cellular glutathione from sulphur mustard.

Key Words: sulphur mustard • benzenethiol • 2,6-dimethoxybenze nethiol • cysteine ester • lung slice

Human & Experimental Toxicology, Vol. 15, No. 8, 619-624 (1996)
DOI: 10.1177/096032719601500804
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