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Human & Experimental Toxicology
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Reference values for young normal Sprague-Dawley rats: weight gain, hematology and clinical chemistry

Len E Lillie

PO Bag 4000, Alberta Environmental Centre, Vegreville, Alberta, Canada T9C 1 T4

Norman J Temple

PO Bag 4000, Alberta Environmental Centre, Vegreville, Alberta, Canada T9C 1 T4

L. Zack Florence

PO Bag 4000, Alberta Environmental Centre, Vegreville, Alberta, Canada T9C 1 T4

1 Arterial blood from 63 male (315 - 500 g) and 60 female (210 - 290 g) healthy Sprague-Dawley rats was ana lyzed for 16 hematological and 22 clinical chemistry parameters.

2 Nine of these parameters were associated with growth and developmental changes in males between 38 - 78 days and females 49 - 89 days of age.

3 Weight gain in both sexes followed patterns consistent with other studies using this strain, but interexperi mental variation was as much as ± 22%.

4 Rectal temperatures of females averaged 37.28°C, being statistically greater (P < 0.05) than the average male at 36.99°C.

5 The data provide reference values for use in toxicolo gical and other investigations.

Key Words: blood chemical analysis • body temperature • electro lytes • body weight

Human & Experimental Toxicology, Vol. 15, No. 8, 612-616 (1996)
DOI: 10.1177/096032719601500802
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