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Changes in sexual behavior of adult male and female rats neonatally treated with vitamin D3

Department of Biology, Semmelweis University of Medicine, Nagyvárad tér 4, PO Box 370, H-1445, Budapest, Hungary

Cs Karabélyos

Department of Biology, Semmelweis University of Medicine, Nagyvárad tér 4, PO Box 370, H-1445, Budapest, Hungary

O. Dobozy

Department of Biology, Semmelweis University of Medicine, Nagyvárad tér 4, PO Box 370, H-1445, Budapest, Hungary

G. Csaba

Department of Biology, Semmelweis University of Medicine, Nagyvárad tér 4, PO Box 370, H-1445, Budapest, Hungary

1 Neonatal treatment of rats with vitamin D₃ resulted in a change of sexual behavior in adulthood.

2 2.5 mg vitamin D ₃ completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D₃ influenced both the desire and ejaculation.

3 Sexual activity of females was depressed by both doses.

4 The experiments demonstrate that vitamin D₃, a steroid in structure, given in the critical period of hormonal imprinting may influence steroid hormone-receptor commanded events for life, in a way similar to the effects exhibited by synthetic steroid hormone analo gues and benzpyrene in earlier studies.

Key Words: vitamin D3 • sexual behavior • hormonal imprinting • steroids • neonatal treatment • perinatal exposure adverse effects

Human & Experimental Toxicology, Vol. 15, No. 7, 573-576 (1996)
DOI: 10.1177/096032719601500704


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