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Human & Experimental Toxicology
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Formation of DNA-adducts by selected sex steroids in rat liver

W. Feser

Research Laboratories, Schering Aktiengesellschaft, 13342 Berlin, Germany

RS Kerdar H Blode

Research Laboratories, Schering Aktiengesellschaft, 13342 Berlin, Germany

R. Reimann

Research Laboratories, Schering Aktiengesellschaft, 13342 Berlin, Germany

1 We are reporting investigations into the potential of the steroid hormones chlormadinone acetate (CMA), cyproterone acetate (CPA), ethinylestradiol (EE2) gestodene (GEST), megestrol acetate (MGA), norethis terone acetate (NET-Ac), estradiol (E 2), and progester one (P) to form DNA-adducts in rat liver in vivo.

2 Compound-related DNA-adduct spots were detected in male and female rat liver following CMA, CPA, and MGA using the 32P-postlabeling-technique. Substance- specific DNA-adducts were also observed in male rats after administration of E2. The other compounds showed no DNA-adduct formation. After treatment with CMA, CPA or MGA, the relative adduct labeling (RAL) differed sex- and substance-specifically.

Key Words: sex steroid hormones • DNA-adduct • 32P-postlabeling assay

Human & Experimental Toxicology, Vol. 15, No. 7, 556-562 (1996)
DOI: 10.1177/096032719601500702
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