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TGF - β1 overexpression in murine pancreas in duces chronic pancreatitis and, together with TNF triggers insulin-dependent diabetes Sanvito F, Nichols A, Herrera P-L, Huarte J, Wohlwend A, Vassalli J-D and Orci L Biochemical and Biophysical Research Communications 1995; 217: 1279-1286

Institute of Pathology 4031, Basel, Switzerland

We have generated transgenic mice overexpressing TGF-β1 in pancreatic β cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganisation of the islets of Langerhans was also observed; how ever, the number of β cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF- in their islet β cells (which also remain normoglycemic) ¹ yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing β cells.

Human & Experimental Toxicology, Vol. 15, No. 6, 540-541 (1996)
DOI: 10.1177/096032719601500614


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