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HFA-134a (1,1,1,2-tetrafluoroethane): effects of inhalation exposure upon reproductive performance, development and maturation of rats

Medicines Safety Evaluation Division, Glaxo Wellcome Research & Development Ltd., Ware, Hertfordshire SG12 ODP

SE Libretto

Medicines Safety Evaluation Division, Glaxo Wellcome Research & Development Ltd., Ware, Hertfordshire SG12 ODP

MJ Adams

Medicines Safety Evaluation Division, Glaxo Wellcome Research & Development Ltd., Ware, Hertfordshire SG12 ODP

EW Hughes

Division of Toxicology, Huntingdon Life Sciences Ltd., PO Box 2, Huntingdon, Cambridgeshire PE18 6ES, UK

M. Bannerman

Division of Toxicology, Huntingdon Life Sciences Ltd., PO Box 2, Huntingdon, Cambridgeshire PE18 6ES, UK

1 HFA-134a was administered to AHA rats by snout-only inhalation for 1 h daily to assess the effects of treatment on reproduction and development.

2 In a fertility study, rats were exposed to atmospheres of 2500, 10000 or 50000 p.p.m. HFA-134a throughout gametogenesis, mating, pregnancy and lactation.

3 In a peri- and post-natal study, rats were exposed to HFA-134a from days 17 to 20 of pregnancy and days 1 to 21 post partum to atmospheres of 1800, 9900 or 64 400 p.p.m.

4 The only treatment-related effect was a slight reduc tion in body weight gain of males of the treated parental generation at 50 000 p.p.m. (fertility study).

5 In neither study were there any adverse effects of HFA- 134a on the reproductive performance of treated animals or on the development, maturation or reproductive performance of up to two successive generations.

Key Words: HFA-134a • inhalation • reproductive toxicology • rats

Human & Experimental Toxicology, Vol. 15, No. 6, 508-517 (1996)
DOI: 10.1177/096032719601500609


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