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Human & Experimental Toxicology
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A search for possible cytogenetic effects of low frequency vibrations in cultured human lymphocytes

Ahmad M Khalil

Department of Biological Sciences, Yarmouk University

W. Qassem

Hijjawi Faculty for Applied Engineering, Yarmouk University, Irbid, Jordan

1 Acute cytogenetic effects expressed as sister-chroma tid exchanges (SCE) in peripheral blood lymphocytes were investigated after in vitro exposure to low vibration regimes (5 - 30 Hz, at 0.1 cm amplitude) for 20 min intervals and compared to non-vibrated control cultures.

2 There was no significant (P<0.05) increase in the range of SCE incidence at any vibration frequency compared to the mean value of control; 6.88 ± 0.11 to 7.97±0.22 versus 6.83±0.86, respectively.

3 When cultures were incubated for 1 h in the presence of 0.5 µg ml-1 mitomycin C (MMC; the positive control) significant elevations in the SCE frequency were observed (19.81 ± 0.67), indicating the sensitivity of the system to in vitro SCE induction.

4 Other cell parameters, such as mitotic index and cell proliferation index were statistically similar in the experimental cultures and the negative control.

5 The observed differences in the investigated end points are considered within those typically found in vitro. This suggests no relation between low frequency vibrations and cytogenetic effects.

Key Words: sister-chromatid exchanges • vibrations • human lym phocytes

Human & Experimental Toxicology, Vol. 15, No. 6, 504-507 (1996)
DOI: 10.1177/096032719601500608
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This article has been cited by other articles:


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 Hum Exp ToxicolHome page
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[Abstract] [PDF]


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