This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Calderón-Salinas, J. Articles by Lopez-Miranda, A. Search for Related Content PubMed PubMed Citation Articles by Calderón-Salinas, J. Articles by Lopez-Miranda, A. Social Bookmarking                         What's this?

Evolution of lead toxicity in a population of children

Department of Biochemistry, CINVESTAV-IPN, México City, México

C. Hernandez-Luna

Department of Biochemistry, Faculty of Biological Sciences, UANL, San Nicolas de Los Garza, NL, México

B. Valdez-Anaya

Department of Biochemistry, Faculty of Medicine, UAC, Torreón, Coah UILA, México

M. Maldonado-Vega

Department of Biochemistry, CINVESTAV-IPN, México City, México

A. Lopez-Miranda

Department of Biochemistry, CINVESTAV-IPN, México City, México

A 3 years study was conducted to determine the evolution of blood lead concentrations (PbB) and free erythrocyte protoporphyrins (FEP) as indicators of absorption and biochemical damage in children (7-12 years old) living within one kilometer of a metallurgic factory that processes lead in Torreón, Coahuila, México. In addition, neuromuscular conduction velocity, motor coordination and IQ where determined as indicators of physiological damage. During this period of time the children showed increased lead blood concentrations of 19.2 ± 4.5 µg dl ^-1 at the beginning of the study to 27.5±4.9 µg dl ^-1 at the end. Likewise, FEP increased from 56.6±20.0 µg dl^-1 to 92.9 ± 28.9 µg dl^-1. Physiological damage was evident since motor coefficients as well as IQ tests were reduced significantly when compared to children (7 -12 years old) living 4.5 km away from the factory who showed PbB=8.9 ± 1.3 µg dl^-1 and FEP=16.9 ± 4.7 µg dl^-1 throughout the study. Based on these data it was possible to define three different groups with regards to lead toxicity sensitivity.

Key Words: lead toxicity • children population • sensitivity to lead

Human & Experimental Toxicology, Vol. 15, No. 5, 376-382 (1996)
DOI: 10.1177/096032719601500502


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?