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Embryotoxicity and teratogenicity studies of poly (DL-Lactide-co-Glycolide) microspheres incorporated tetanus toxoid in Wistar rats

Division of Toxicology, National Institute of Immunology, New Delhi 110 067, India

DK Giri

Division of Toxicology, National Institute of Immunology, New Delhi 110 067, India

M Roy Chaudhury

Division of Toxicology, National Institute of Immunology, New Delhi 110 067, India

Tetanus Toxoid loaded biodegradable microspheres (MTT) (poly (DL-Lactide-co-Glycolide) were administered intramuscularly to pregnant Wistar rats from Days 6 to 15 of gestation, at 1, 5 and 10-times the human equivalent dose of TT. Developmental defects in relation to soft tissues and skeleton, weight and sex of live pups and early fetal deaths from treated and control rats were analysed. The findings in treatment groups were comparable to those in the controls. These observations show that MTT was safe for pregnant rats and developing pups.

Key Words: biodegradable polymer • vaccine • tetanus toxoid • teratogenicity

Human & Experimental Toxicology, Vol. 15, No. 4, 349-351 (1996)
DOI: 10.1177/096032719601500411


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