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Histopathological effects of Illudin S, a toxic substance of poisonous mushroom, in rat

National Research Institute of Police Science, 6, Sanban-cho, Chiyoda-ku, Tokyo 102, Japan

S. Miyasaka

National Research Institute of Police Science, 6, Sanban-cho, Chiyoda-ku, Tokyo 102, Japan

T. Inoue

National Research Institute of Police Science, 6, Sanban-cho, Chiyoda-ku, Tokyo 102, Japan

1 Rats were dosed orally with illudin S, a toxic substance derived from the poisonous mushroom Lampteromyces japonicus. The digestive tract showed severe damage, whereas the liver, kidney and lung did not show any significant changes.

2 The effects observed became more pronounced with increasing illudin S dose (5, 10 or 20 mg kg ^-1 body weight).

3 Severe inflammation and oedema were observed in the stomach and moderate changes in the proximal part of the small intestine.

4 Histopathological examination revealed haemorrha gic erosions and marked inflammatory oedema in the gastric mucosa.

Key Words: illudin S • histopathological changes • inflation • oede ma • haemorrhagic erosion

Human & Experimental Toxicology, Vol. 15, No. 4, 289-293 (1996)
DOI: 10.1177/096032719601500403


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