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Elevated amylase is related to the development of respiratory failure in organophosphate poisoning

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

M. Tanaka

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

M. Iwai

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

T. Kondo

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

S. Takahashi

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

S. Sato

Department of Anesthesiology and Critical Care Medicine, TsuchiuraKyodo General Hospital, 11-7Manabeshinnmachi, Tsuchiura, Ibaraki, 300, Japan, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

1 A retrospective study of organophosphate(OP) poison ing in the intensive care unit was performed to analyze the incidence of respiratory failure.

2 The patients were treated initially with gastrointest inal decontamination including gastric lavage and the administration of activated charcoal with cathartic. Further management included intravenous pralidoxim and atropine and ventilatory support.

3 Of the 32 OP poisoning patients, 16 patients developed respiratory failure and received ventilatory support. 4 An increase in plasma amylase above the normal range on the day of admission was related to the development of respiratory failure.

5 In OP poisoning, the elevation of amylase level was predictive of the subsequent respiratory failure.

Key Words: organophosphate poisoning • respiratory failure • amy lase

Human & Experimental Toxicology, Vol. 15, No. 3, 250-253 (1996)
DOI: 10.1177/096032719601500311


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