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Transplacental passage of [3H]-okadaic acid in pregnant mice measured by radioactivity and high-performance liquid chromatography

Laboratory of Toxicology and Applied Hygiene, Unité de formation et de recherche des Sciences Pharmaceutiques, University of Bordeaux 2, 3 ter, Place de la Victoire, 33076 Bordeaux, France

EE Creppy

Laboratory of Toxicology and Applied Hygiene, Unité de formation et de recherche des Sciences Pharmaceutiques, University of Bordeaux 2, 3 ter, Place de la Victoire, 33076 Bordeaux, France

Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopan creas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the first time that this marine toxin is able to cross the transplacental barrier.

Foetal tissue contains more okadaic acid than the liver or kidney: 5.60% compared to 1.90 and 2.55% respectively as measured by HPLC and fluorescent detection after derivatization with 9-Anthryldiazomethane (ADAM). In view of its adverse effects, okadaic acid might impair foetal development and promote tumours in neonates.

Key Words: [3H]-labelled • okadaic acid • female mice • transplacental passage • foetus • HPLC • fluorescent detec tion

Human & Experimental Toxicology, Vol. 15, No. 3, 226-230 (1996)
DOI: 10.1177/096032719601500307


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