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Human & Experimental Toxicology
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Poly (D,L-Lactide) glycolide polymer microsphere entrapped tetanus toxoid: safety evaluation in Wistar rats

M. Roy Chaudhury

National Institute of Immunology, Aruna Asaf Ali Marg, JNU Complex, New Delhi-67, India

K. Sharma

National Institute of Immunology, Aruna Asaf Ali Marg, JNU Complex, New Delhi-67, India

DK Giri

National Institute of Immunology, Aruna Asaf Ali Marg, JNU Complex, New Delhi-67, India

A vaccine preparation consisting of tetanus toxoid (TT) encapsulated in biodegradable poly (D,L-Lactide) glyco lide polymer has been developed. The toxicity of the preparation was evaluated in adult male and female Wistar rats injected IM with 20, 100 and 200 Lf tetanus toxoid, in polymer in 0.5 ml vehicle. No adverse effect of the vaccine could be seen, except for a granulomatous reaction at the site of injection. The vaccine was considered safe based on the findings in rats of both sexes.

Key Words: biodegradable polymer • tetanus toxoid • vaccine • toxicity

Human & Experimental Toxicology, Vol. 15, No. 3, 205-207 (1996)
DOI: 10.1177/096032719601500303
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