This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Toet, A. Articles by de Wildt, D. Search for Related Content PubMed PubMed Citation Articles by Toet, A. Articles by de Wildt, D. Social Bookmarking                         What's this?

Reduced survival after isoprenaline/ dopamine in d,l-propranolol intoxicated rats

National Poison Control Centre, National Institute of Public Health and Environmental Protection, Department of Intensive Care and Clinical Toxicology, Utrecht University Hospital, PO Box 85.500, 3508 GA Utrecht, The Netherlands

JD te Biesebeek

Laboratory of Toxicology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands

W. Vleeming

Laboratory of Toxicology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands

J. Wemer

Laboratory of Toxicology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands

J. Meulenbelt

National Poison Control Centre, National Institute of Public Health and Environmental Protection, Department of Intensive Care and Clinical Toxicology, Utrecht University Hospital, PO Box 85.500, 3508 GA Utrecht, The Netherlands

DJ de Wildt

Laboratory of Toxicology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA Bilthoven, The Netherlands, Rudolf Magnus Institute for Neuroscience, Department of Medical Pharmacology, Utrecht University, PO Box 80.040, 3508 TA Utrecht, The Netherlands

1 Respiratory and cardiovascular failure are principle toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats.

2 The effect of β-adrenoceptor agonists on respiratory and cardiovascular failure in β-blocker overdose was investigated in a model of acute d,l-propranolol (30 mg kg ^-1 h^-1) intoxication in spontaneously breathing rats.

3 Neither the aselective, hydrophilic β-agonist isoprena line (10, 25, 50 µg kg^-1 min^-1), nor the β ₁-selective, lipophilic β-agonist flerobuterol (1,3,10 µ g kg^-1 min^-1) and the β₂-selective, lipophilic β-agonist clenbuterol (10, 25, 50 µg kg^-1 min^-1) had any beneficial effect on cardiovascular and respiratory variables or survival time in d,l-propranolol intoxicated spontaneously breathing rats.

4 Isoprenaline (10 µg kg^-1 min^-1) had no favourable effect on haemodynamic and respiratory variables in artificially ventilated d,l -propranolol intoxicated rats either.

5 Addition of dopamine to isoprenaline resulted in a significant reduction of survival time, primarily caused by a decrease in mean arterial blood pressure, in artificially ventilated d,l-propranolol intoxicated rats. Addition of glucagon to isoprenaline did not affect survival time. 6 Artificial ventilation is the most important supportive measure in d,l-propranolol intoxication in the rat.

Key Words: propranolol intoxication • β-adrenoceptor agonists • dopamine • isoprenaline • survival

Human & Experimental Toxicology, Vol. 15, No. 2, 120-128 (1996)
DOI: 10.1177/096032719601500204


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. Zaugg, M. C. Schaub, T. Pasch, and D. R. Spahn Modulation of {beta}-adrenergic receptor subtype activities in perioperative medicine: mechanisms and sites of action Br. J. Anaesth., January 1, 2002; 88(1): 101 - 123. [Abstract] [Full Text] [PDF]