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Changes in cholinesterase activities after daunorubicin administration to rabbits

V. Gerl

Department of Pharmacology, Faculty of Medicine, Charles University, Hradec Králové

J. Bajgar

Military Medical Academy, Hradec Králové

O. Krs

Military Medical Academy, Hradec Králové

R. Hrdina

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové

V. Palika

Institute of Clinical Biochemistry and Diagnostics, University Hospital, Hradec Králové

Y. Mazurová

Department of Histology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic

1 Acetyl- and butyrylcholinesterase (AChE, BuChE) activities were studied in rabbits with experimentally induced daunorubicin cardiomyopathy.

2 A significant decrease of the plasma BuChE in the daunorubicin group was observed.

3 In the daunorubicin group, AChE activity in the heart was significantly decreased only in the interventricu lar septum.

4 BuChE activity was significantly decreased in the cardiac septum and ventricles and in the liver following daunorubicin treatment.

5 Changes in cholinesterase activities are probably caused by an effect of daunorubicin oon protein synthesis during the development of certain types of cardiomyopathy.

Key Words: cholinesterases • heart • rabbit • daunorubicin • plasma

Human & Experimental Toxicology, Vol. 15, No. 10, 834-838 (1996)
DOI: 10.1177/096032719601501007


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