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Human & Experimental Toxicology
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What's this?

Some immunological parameters in workers occupationally exposed to n-hexane

A. Karakaya

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara

B. Yücesoy

Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandogan, Ankara

S. Burgaz

Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara

HU Sabir

National Institute of Occupational Safety and Health, Etimesgut, Ankara, Turkey

AE Karakaya

Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330, Hipodrom, Ankara

1 To estimate the quantitative relation between exposure to airborne n-hexane and various markers of immune function, 35 male workers were examined and compared with unexposed controls.

2 Urinary 2,5-hexanedione concentrations were signifi cantly higher in the exposed group than in the unexposed.

3 A significant suppression was observed in the serum immunoglobulin (IgG, IgM and IgA) levels between two populations. Also, a significant correlation was found between urinary 2,5-hexanedione concentrations and serum Ig level of the exposed group.

4 No significant difference between white blood cell counts was found in the two groups.

Key Words: n-hexane • 2,5-hexanedione • industrial solvents • urine • immunology

Human & Experimental Toxicology, Vol. 15, No. 1, 56-58 (1996)
DOI: 10.1177/096032719601500110
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