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Human & Experimental Toxicology
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Skin irritation testing in man for hazard assessment — evaluation of four patch systems

M. York

Unilever, Enviromental Safety Laboratory, Colworth House, Shambrook, Bedford MK44 1LQ

DA Basketter

Unilever, Enviromental Safety Laboratory, Colworth House, Shambrook, Bedford MK44 1LQ

JA Cuthbert

Inveresk Research International Limited, Tranent, Scotland, EH33 2NE

L. Neilson

Inveresk Research International Limited, Tranent, Scotland, EH33 2NE

1 The limitations of the Draize rabbit skin irritation test for hazard evaluation for man are widely documented. Nevertheless it remains the prescribed method for deter mining acute skin irritation hazard.

2 While the use of human testing for risk assessment of irritants is well established, the use of predictive testing in man for hazard identification has not been explored widely, and this is the object of the research programme.

3 The experiment described in this report evaluates the sensitivity of four patch testing systems (Finn chamber, Hill Top patch, Van der Bend chamber, and Webril patch) using a total of six irritant substances.

4 Following preliminary range-finding experiments, test materials were applied to the upper outer arm for up to 4 h. Assessments were performed immediately after patch removal and at 1, 24, 48 and 72 h.

5 Webril and Hill Top patches generated the greatest lev els of response, although responses with Finn and Van der Bend were observed. Hill Top patches are recom mended for future development work.

6 The use of very small preliminary panels to predict the effects in larger panels using different volunteers was only of limited value as each volunteer was found to have different irritant thresholds.

Key Words: skin • irritation • hazard • patch • man

Human & Experimental Toxicology, Vol. 14, No. 9, 729-734 (1995)
DOI: 10.1177/096032719501400906
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