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Human & Experimental Toxicology
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Intrapleural administration of vitreous high duty ceramic fibres and heated devitrified ceramic fibres does not give rise to pleural mesothelioma in rats

P. Carthew

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN

RE Edwards

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN

BM Dorman

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN

RC Brown

MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN

J. Young

School of Science and Materials Research Institute, Sheffield Hallam University, Pond Street, Sheffield S1 1WB

JJ Laskowski

School of Science and Materials Research Institute, Sheffield Hallam University, Pond Street, Sheffield S1 1WB

JC Wagner

c/o MRC Toxicology Unit, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester LE1 9HN, UK

In order to determine whether they are potentially car cinogenic to the pleural mesothelium, three samples of ceramic fibre have been administered to rats by the intrapleural route. These samples were a high-duty grade refractory ceramic fibre (manufactured by Thermal Ceramics Ltd) in the as-manufactured vitreous state and two devitrified samples produced by heating the same fibre for 2 weeks at 1200°C and for two weeks at 1400°C. The mean lifespans of the groups of rats treated with vitri fied and devitrified ceramic fibres were not significantly different from that of the control rats. In these studies none of the treated or control rats developed pleural mesothelioma, making it unlikely that ceramic fibres of this type, whether vitreous or devitrified, are potentially carcinogenic to the pleural mesothelium.

Key Words: mesothelioma • tumour • fibre • ceramic • devitrified

Human & Experimental Toxicology, Vol. 14, No. 8, 657-661 (1995)
DOI: 10.1177/096032719501400806
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