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Human & Experimental Toxicology
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Fenoverine-induced rhabdomyolysis

P. Chariot

Department of Toxicology, Université Paris 12, Department of Pathology (Neuropathology), Université Paris 12, Unit of Neuromuscular Disorders (ER 269), Université Paris 12

R. Ratiney

Department of Toxicology, Université Paris 12

F. Le Maguet

Unit of Neuromuscular Disorders (ER 269), Université Paris 12

V. Fourestié

Department of Medical Emergencies, Hôpital Henri Mondor, 94 000 Créteil, France

A. Astier

Department of Toxicology, Université Paris 12

R. Gherardi

Department of Pathology (Neuropathology), Université Paris 12, Unit of Neuromuscular Disorders (ER 269), Université Paris 12

Fenoverine is a spasmolytic drug that inhibits calcium channel currents. We describe the clinicopathologic find ings in two patients with fenoverine-induced rhabdomyo lysis, of whom one died. A transient left-bundle-branch block was observed in both patients. In one case, pre-exist ing hepatic dysfunction may have induced accumulation of the drug. Concurrent treatment by fibrates, as observed in the second patient, may have been a predisposing factor for fenoverine-induced rhabdomyolysis. The incidence of muscular complications of fenoverine therapy could be reduced by avoidance of prescription of the drug in patients with hepatopathy or those being treated with cho lesterol-lowering agents. Physicians should be aware of life-threatening adverse effects of apparently innocuous drugs.

Key Words: fenoverine • rhabdomyolysis • ischemia • spas molytic drug

Human & Experimental Toxicology, Vol. 14, No. 8, 654-656 (1995)
DOI: 10.1177/096032719501400805
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