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Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, Nussbaumstr. 26, D-80336 München, Germany

A. Kleine

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, Nussbaumstr. 26, D-80336 München, Germany

L. Szinicz

Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, Nussbaumstr. 26, D-80336 München, Germany

1 The effect of pyridostigmine on cardiorespiratory func tion after oxime+atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning.

2 The trachea, a carotid artery and jugular vein were can nulated in female urethane-anaesthetised Pirbright white guinea-pigs. After baseline measurements the ani mals received pyridostigmine (0.05 µmol kg^-1) and 30 min later atropine (29.5 µmol kg^-1) plus obidoxime, HI 6 or HL6 7 (30 or 100 µmol kg^-1) or tabun (1.85 µmol kg^-1 = 5 x LD₅₀) followed by oxime+atropine treatment (all i.v.). Erythrocyte, brain and diaphragm acetyl cholinesterase (AChE) activity were determined. Similar groups without pretreatment were included for compar ison.

3 Pyridostigmine aggravated the oxime+atropine induced hypotension and prevented the increase in heart rate but not the respiratory stimulation. The pyridostigmine inhibited AChE recovered only in the 100 µmol kg^-1 kg oxime groups at the end of the experiment.

4 In tabun poisoning, pyridostigmine reduced the oxime+atropine induced circulatory recovery and decreased the survival time and rate. It did not affect the therapeutic oxime+atropine effect on respiratory function.

5 These results suggest that pyridostigmine enhances oxime+atropine related circulatory depression which may be the reason for the reduced efficacy of oxime+atropine treatment in tabun poisoning. The pos sible mechanisms are discussed.

Key Words: tabun • pyridostigmine pretreatment • HI 6 • HLö 7 • car diorespiratory effects

Human & Experimental Toxicology, Vol. 14, No. 8, 634-642 (1995)
DOI: 10.1177/096032719501400803


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