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Ochratoxin A in human blood in relation to nephropathy in Tunisia

Laboratoire de Biochimie et de Toxicologie Moléculaire, Faculté de Médecine Dentaire, rue Avicenne, 5019 Monastir, Tunisia

A. Achour

Laboratoire de Biochimie et Service de Néphrologie, Faculté de Médecine et Centre Hospitalier Universitaire de Monastir, rue Avicenne, 5019 Monastir, Tunisia

M. Hammami

Laboratoire de Biochimie et Service de Néphrologie, Faculté de Médecine et Centre Hospitalier Universitaire de Monastir, rue Avicenne, 5019 Monastir, Tunisia

M. El May

Laboratoire de Biochimie et Service de Néphrologie, Faculté de Médecine et Centre Hospitalier Universitaire de Monastir, rue Avicenne, 5019 Monastir, Tunisia

AM Betbeder

Laboratoire de Toxicologie et d'Hygiène Appliquée, Unité de Formation et de Recherche des Sciences Pharmaceutiques, Université de Bordeaux 2, 3ter place de la Victoire, 33000 Bordeaux Cedex, France

F. Ellouz

Laboratoire de Biochimie et de Toxicologie Moléculaire, Faculté de Médecine Dentaire, rue Avicenne, 5019 Monastir, Tunisia

EE Creppy

Laboratoire de Toxicologie et d'Hygiène Appliquée, Unité de Formation et de Recherche des Sciences Pharmaceutiques, Université de Bordeaux 2, 3ter place de la Victoire, 33000 Bordeaux Cedex, France

H. Bacha

Laboratoire de Biochimie et de Toxicologie Moléculaire, Faculté de Médecine Dentaire, rue Avicenne, 5019 Monastir, Tunisia

The determination of ochratoxin A (OTA) in human blood in Tunisian populations is underway. The range of conta mination is between 0.7 to 7.8 ng ml^-1 for the general popu lation and 12 to 55 ng ml^-1 for people suffering from chron ic renal failure. It appears that 21 to 64% of people suffer ing from nephropathy are OTA positive with a detection limit of 1ng ml^-1. This situation prompted us to search for possible association of OTA contamination and nephropa thy resembling Balkan endemic nephropathy. The classifi cation of the ill population into chronic interstitial nephropathy (CIN), chronic glomerular nephropathy (CGN), chronic vascular nephropathy (CVN) and others, indicated that the largest is the CIN group which is signifi cantly different from the other groups, and from the con trol (P < 0.005). Furthermore, it presented the highest OTA mean values (25 to 59 ng ml^-1) compared with the control, CGN, CVN and other groups (6 to 18 ng ml^-1) according to the designated region in Tunisia.

The rural population seems to be more exposed to ochratoxins in Tunisia, as has been previously reported in the Balkans and Western Europe.

Altogether, these results emphasise that in Tunisia an endemic ochratoxin-related nephropathy is probably occurring.

Key Words: ochratoxin A • human blood • nephropathy • Tunisia

Human & Experimental Toxicology, Vol. 14, No. 7, 609-614 (1995)
DOI: 10.1177/096032719501400710


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