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Effect of dermal application of hexachlorocyclohexane (HCH) on male reproductive system of rat

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

N. Pant

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

SC Srivastava

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

R. Kumar

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

SP Srivastava

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

1 The toxic manifestations of dermally applied hexa chlorocyclohexane (50 mg or 100 mg kg^-1 body weight day ^-1, 5 days in a week for 120 days) on testes and sperm of rat have been investigated.

2 The results indicate that exposure of HCH through the dermal route could lead to an alteration in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH), -glutamyl transpeptidase (-GT) and β-glucuronidase (βGluc.) associ ated with specific cell types.

3 Significant quantities of HCH and its isomers accumu lated in testes as well as sperm of treated rats.

4 HCH exposure also led to a decrease in serum testos terone levels, epididymal sperm count, sperm motility and an increase in the percentage of abnormal sperm. 5 These observations indicate the possibility of adverse effects of HCH on the male reproductive functions of men exposed dermally to this pesticide in industry or during spraying in the field.

Key Words: hexachlorocyclohexane • reproductive system • rat • testes • sperm

Human & Experimental Toxicology, Vol. 14, No. 6, 484-488 (1995)
DOI: 10.1177/096032719501400603


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