This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Prasad, A. Articles by Srivastava, S. Search for Related Content PubMed PubMed Citation Articles by Prasad, A. Articles by Srivastava, S. Social Bookmarking                         What's this?

Effect of dermal application of hexachlorocyclohexane (HCH) on male reproductive system of rat

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

N. Pant

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

SC Srivastava

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

R. Kumar

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

SP Srivastava

Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow-226 001, UP, India

1 The toxic manifestations of dermally applied hexa chlorocyclohexane (50 mg or 100 mg kg^-1 body weight day ^-1, 5 days in a week for 120 days) on testes and sperm of rat have been investigated.

2 The results indicate that exposure of HCH through the dermal route could lead to an alteration in the activities of marker testicular enzymes viz. sorbitol dehydrogenase (SDH), glucose-6-P-dehydrogenase (G6PDH), -glutamyl transpeptidase (-GT) and β-glucuronidase (βGluc.) associ ated with specific cell types.

3 Significant quantities of HCH and its isomers accumu lated in testes as well as sperm of treated rats.

4 HCH exposure also led to a decrease in serum testos terone levels, epididymal sperm count, sperm motility and an increase in the percentage of abnormal sperm. 5 These observations indicate the possibility of adverse effects of HCH on the male reproductive functions of men exposed dermally to this pesticide in industry or during spraying in the field.

Key Words: hexachlorocyclohexane • reproductive system • rat • testes • sperm

Human & Experimental Toxicology, Vol. 14, No. 6, 484-488 (1995)
DOI: 10.1177/096032719501400603


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				G. La Sala, D. Farini, and M. De Felici Proapoptotic Effects of Lindane on Mouse Primordial Germ Cells Toxicol. Sci., April 1, 2009; 108(2): 445 - 451. [Abstract] [Full Text] [PDF]

				E. Corcelle, M. Nebout, S. Bekri, N. Gauthier, P. Hofman, P. Poujeol, P. Fenichel, and B. Mograbi Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Activity. Cancer Res., July 1, 2006; 66(13): 6861 - 6870. [Abstract] [Full Text] [PDF]

				S. L. Farr, J. Cai, D. A. Savitz, D. P. Sandler, J. A. Hoppin, and G. S. Cooper Pesticide Exposure and Timing of Menopause: The Agricultural Health Study Am. J. Epidemiol., April 15, 2006; 163(8): 731 - 742. [Abstract] [Full Text] [PDF]

				S. L. Farr, G. S. Cooper, J. Cai, D. A. Savitz, and D. P. Sandler Pesticide Use and Menstrual Cycle Characteristics among Premenopausal Women in the Agricultural Health Study Am. J. Epidemiol., December 15, 2004; 160(12): 1194 - 1204. [Abstract] [Full Text] [PDF]

				B. Mograbi, E. Corcelle, N. Defamie, M. Samson, M. Nebout, D. Segretain, P. Fenichel, and G. Pointis Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway Carcinogenesis, August 1, 2003; 24(8): 1415 - 1423. [Abstract] [Full Text] [PDF]

				U Mani, F Islam, A K Prasad, P Kumar, V S. Kumar, B K Maji, and K K Dutta Steroidogenic alterations in testes and sera of rats exposed to formulated Fenvalerate by inhalation Human and Experimental Toxicology, November 1, 2002; 21(11): 593 - 597. [Abstract] [PDF]

				N. Defamie, B. Mograbi, C. Roger, L. Cronier, A. Malassine, F. Brucker-Davis, P. Fenichel, D. Segretain, and G. Pointis Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells Carcinogenesis, September 1, 2001; 22(9): 1537 - 1542. [Abstract] [Full Text] [PDF]

				M Suwalsky, F Villena, D Marcus, and A M Ronco Plasma absorption and ultrastructural changes of rat testicular cells induced by lindane Human and Experimental Toxicology, September 1, 2000; 19(9): 529 - 533. [Abstract] [PDF]

				L. P. Walsh and D. M. Stocco Effects of Lindane on Steroidogenesis and Steroidogenic Acute Regulatory Protein Expression Biol Reprod, April 1, 2000; 63(4): 1024 - 1033. [Abstract] [Full Text]

				T. J. Schrader and G. M. Cooke Examination of Selected Food Additives and Organochlorine Food Contaminants for Androgenic Activity in Vitro Toxicol. Sci., February 1, 2000; 53(2): 278 - 288. [Abstract] [Full Text] [PDF]