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Amisulpride poisoning: a report on two cases

Institut de Médecine Légale, Faculté de Médecine de Strasbourg, 11 rue Humann, 67085 Strasbourg

C. Mutter-Schmidt

Département d'Anesthésiologie, CHRU / Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg

P. Kintz

Institut de Médecine Légale, Faculté de Médecine de Strasbourg, 11 rue Humann, 67085 Strasbourg

C. Berton

Service de Réanimation Médicale et Centre Anti-Poisons, Pavillon Pasteur, CHRU / Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg Cedex, France

P. Mangin

Institut de Médecine Légale, Faculté de Médecine de Strasbourg, 11 rue Humann, 67085 Strasbourg

The first two observations of human poisoning involving the recently developed neuroleptic amisulpride are described. In both cases drug determination was per formed using reversed-phase HPLC coupled with diode- array detection. Case 1 was a nonfatal overdosage in which the ingestion of 3.0 g amisulpride induced an attack of seizures, then light coma with agitation, hyperthermia, mydriasis, minimal extrapyramidal features, tachycardia and slight prolongation of the QT interval; the blood con centration of amisulpride was 9.63 µg ml-1. Case 2 was a fatality attributed to amisulpride in which the measured blood concentration was 41.70 µg ml-1. Our results are discussed in the light of data previously reported on the toxicity of substituted benzamides.

Key Words: amisulpride • neuroleptic • poisoning • toxicology • liquid chromatography

Human & Experimental Toxicology, Vol. 14, No. 3, 294-298 (1995)
DOI: 10.1177/096032719501400310


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