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Human metabolism of aluminium-26 and gallium-67 injected as citrates

Biomedical Research Department, AEA Technology, 551 Harwell, Didcot, Oxon, OX11 ORA, UK

D. Newton

Biomedical Research Department, AEA Technology, 551 Harwell, Didcot, Oxon, OX11 ORA, UK

JP Day

Department of Chemistry, University of Manchester, Manchester M13 9PL, UK

RJ Talbot

Biomedical Research Department, AEA Technology, 551 Harwell, Didcot, Oxon, OX11 ORA, UK

AJ Warner

Biomedical Research Department, AEA Technology, 551 Harwell, Didcot, Oxon, OX11 ORA, UK

1 ²⁶Al and ⁶⁷Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by y-ray spectrometry and/or accelerator mass spectrometry.

2 More than half of the ²⁶Al had left the blood after 15 min and the decline continued, leaving <1% in blood after 2 d; the losses occurred both to renal excretion and through uptake by other compartments. Estimated excre tion up to 13 d was 83% (urine) and 1.8% (faeces). Whole-body retention of 15% at 13 d declined to 4% at 1178 d, when the daily reduction corresponded to a bio logical half-life of 7 y, suggesting that sustained intake of dietary aluminium may lead to a progressively increas ing internal deposit.

3 The metabolism of ⁶⁷Ga differed markedly from that of ²⁶Al in all aspects studied.

Key Words: aluminium • gallium • injection • retention • excretion

Human & Experimental Toxicology, Vol. 14, No. 3, 287-293 (1995)
DOI: 10.1177/096032719501400309


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