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Human & Experimental Toxicology
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Superoxide radical and toxicity of environmental nickel exposure

Elb Novelli

Departamento de Quimica, Instituto de Biociências, Universidade Estadual Paulista, UNESP, 18618 000, Botucatu, São Paulo, Brasil

NL Rodrigues

Departamento de Quimica, Instituto de Biociências, Universidade Estadual Paulista, UNESP, 18618 000, Botucatu, São Paulo, Brasil

BO Ribas

Instituto de Salud Carlos , Ministerio de Sanidad y Consumo, Madrid, Spain

Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg-1). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl 2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol pre vented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.

Key Words: nickel • superoxide radical • toxicity • superoxide dismutase • rats

Human & Experimental Toxicology, Vol. 14, No. 3, 248-251 (1995)
DOI: 10.1177/096032719501400303
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