This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Alison, M. R Articles by Sarraf, C. E Search for Related Content PubMed PubMed Citation Articles by Alison, M. R Articles by Sarraf, C. E Social Bookmarking                   What's this?

Review : Apoptosis: regulation and relevance to toxicology

Department of Histopathology, RPMS, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

Catherine E Sarraf

Department of Histopathology, RPMS, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

1 Apopotosis is a remarkably stereotyped morphological event across all tissues in response to a vast array of dam aging agents.

2 Our very existence depends upon a willing exchange of old life for new: apoptotic cell death is our guardian and saviour from genetic damage.

3 There is a close link between cell proliferation and apoptosis: When a cell picks up the machinery to prolifer ate it also acquires an abort pathway - 'better dead than wrong'.

4 A wide variety of highly conserved genes have been implicated in triggering apoptosis.

5 The release of DNA loops from the nuclear scaffold is a more crucial intracellular event than DNA 'laddering' in apoptotic cells.

6 The manipulation of apoptotic rates in many of the common diseases in man will be a major therapeutic strategy in the future.

Key Words: apoptosis • DNA • cell death • review

Human & Experimental Toxicology, Vol. 14, No. 3, 234-247 (1995)
DOI: 10.1177/096032719501400302


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				Y. Otake, A. Mims, and D. J. Fernandes Merbarone Induces Activation of Caspase-Activated DNase and Excision of Chromosomal DNA Loops from the Nuclear Matrix Mol. Pharmacol., April 1, 2006; 69(4): 1477 - 1485. [Abstract] [Full Text] [PDF]

				H. Martin, L. Richert, and A. Berthelot Magnesium Deficiency Induces Apoptosis in Primary Cultures of Rat Hepatocytes J. Nutr., August 1, 2003; 133(8): 2505 - 2511. [Abstract] [Full Text] [PDF]

				M. J. Gomez-Lechon, E. O'Connor, J. V. Castell, and R. Jover Sensitive Markers Used to Identify Compounds That Trigger Apoptosis in Cultured Hepatocytes Toxicol. Sci., February 1, 2002; 65(2): 299 - 308. [Abstract] [Full Text] [PDF]

				U. Namgung and Z. Xia Arsenite-Induced Apoptosis in Cortical Neurons Is Mediated by c-Jun N-Terminal Protein Kinase 3 and p38 Mitogen-Activated Protein Kinase J. Neurosci., September 1, 2000; 20(17): 6442 - 6451. [Abstract] [Full Text] [PDF]

				M. El Mouedden, G. Laurent, M.-P. Mingeot-Leclercq, H. S. Taper, J. Cumps, and P. M. Tulkens Apoptosis in Renal Proximal Tubules of Rats Treated with Low Doses of Aminoglycosides Antimicrob. Agents Chemother., March 1, 2000; 44(3): 665 - 675. [Abstract] [Full Text]

				A De Santiago and M Aguilar-Santelises Organotin compounds decrease in vitro survival, proliferation and differentiation of normal human B lymphocytes Human and Experimental Toxicology, October 1, 1999; 18(10): 619 - 624. [Abstract] [PDF]

				B. G. Short, D. M. Zimmerman, and L. W. Schwartz Automated Double Labeling of Proliferation and Apoptosis in Glutathione S-transferase-positive Hepatocytes in Rats J. Histochem. Cytochem., September 1, 1997; 45(9): 1299 - 1306. [Abstract] [Full Text] [PDF]

				T. L. Goldsworthy, R. Fransson-Steen, and R. R. Maronpot Importance of and Approaches to Quantification of Hepatocyte Apoptosis Toxicol Pathol, January 1, 1996; 24(1): 24 - 35. [Abstract] [PDF]

				G. L. Kedderis Biochemical Basis of Hepatocellular Injury Toxicol Pathol, January 1, 1996; 24(1): 77 - 83. [Abstract] [PDF]