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Human & Experimental Toxicology
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Effects of variation in detoxification rate on dose monitoring through adducts

U. Föst

Institut für Arbeitsphysiologie an der Universität Dortmund

M. Törnqvist

Department of Radiobiology, Stockholm University

M. Leutbecher

Institut für Arbeitsphysiologie an der Universität Dortmund

F. Granath

Institute of Actuarial Mathematics and Mathematical Statistics, Stockholm University, Sweden

E. Hallier

Institut für Arbeitsphysiologie an der Universität Dortmund

L. Ehrenberg

Department of Radiobiology, Stockholm University

1 Föst et al. ( Human & Experimental Toxicology 1991; 10: 25) have shown that ethylene oxide (EO) added to human blood gave rise to a higher level of adducts to haemoglobin (Hb) when the donors were deficient in an erythrocytic glutathione S-transferase (GST, later found to be GST-theta) than in blood from persons pos sessing this enzyme, and drew the conclusion that this polymorphism in detoxification rendered Hb adducts less suitable for biological monitoring.

2 By fitting a kinetic model to the data, the present study shows that the Hb adduct level gives a correct measure of the dose (concentration integrated over time) rele vant to risk estimation.

3 It does illustrate, however, the importance of knowing an individual's detoxification efficiency, when Hb adduct measurements are used to assess environmen tal exposure, for example in occupational surveillance.

Key Words: ethylene oxide • hemoglobin adducts • GST-poly morphism • GST-theta • dose

Human & Experimental Toxicology, Vol. 14, No. 2, 201-203 (1995)
DOI: 10.1177/096032719501400208
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