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Human & Experimental Toxicology
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A new route to thyrotoxicosis?

Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis AF Howie, SW Walker, B Akesson, JR Arthur, GJ Beckett. Biochemical Journal 1995; 308: 713-717

Gerry Thomas

Department of Histopathology, University of Cambridge, UK

Human thyrocytes were found to synthesise and secrete the selenoenzyme extracellular glutathione peroxidase (E-GPX), a process which was controlled by the Ca2+/phosphoinositol second messenger cas cade. The potential involvement of thyroidal E-GPX in the regulation of thyroid hormone synthesis and in the protection of the thyrocyte from peroxidative damage is discussed.

Human & Experimental Toxicology, Vol. 14, No. 12, 994-995 (1995)
DOI: 10.1177/096032719501401210
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