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Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate

Institute of Hygiene and Preventive Medicine, Medical Faculty, Charles University, Simkova 870, 500 38 Hradec Kralove, Czech Republic

A. Vyskocil

Département de Médecine du Travail et Hygiéne du Milieu, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, Québec, Canada, H3C 3J7

Z. Fiala

Institute of Hygiene and Preventive Medicine, Medical Faculty, Charles University, Simkova 870, 500 38 Hradec Kralove, Czech Republic

M. Cizkova

Institute of Hygiene and Preventive Medicine, Medical Faculty, Charles University, Simkova 870, 500 38 Hradec Kralove, Czech Republic

1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months.

2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.

3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.

4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion).

Key Words: nickel • body fluids • organs • rats

Human & Experimental Toxicology, Vol. 14, No. 12, 955-958 (1995)
DOI: 10.1177/096032719501401204


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