SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kassa, J.
Right arrow Articles by Bajgar, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kassa, J.
Right arrow Articles by Bajgar, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methyl phosphonofluoridate (GF) in rats

J. Kassa

Purkyne Military Medical Academy, Hradec Králové, Czech Republic

J. Bajgar

Purkyne Military Medical Academy, Hradec Králové, Czech Republic

1 The efficacy of HI-6 and obidoxime in combination with atropine on cyclohexyl methylphosphonofluoridate (GF)- induced cholinergic and stressogenic effects in rats was studied.

2 HI-6 sufficiently reactivated cholinesterase activity in blood as well as acetylcholinesterase activity in brain and diaphragm following GF intoxication, and practically eliminated stressogenic effects of GF (an increase in plas ma corticosterone level and liver tyrosine aminotrans ferase activity).

3 Obidoxime had practically no effect on enzyme activity or stressogenic effects of GF agent.

4 These findings confirm that HI-6 has definite advan tages over obidoxime in the treatment of intoxication with GF.

Key Words: GF agent • HI-6 • obidoxime • atropine • acetyl cholinesterase • corticosterone • tyrosine aminotransferase

Human & Experimental Toxicology, Vol. 14, No. 11, 923-928 (1995)
DOI: 10.1177/096032719501401111
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 International Journal of ToxicologyHome page
L. Bartosova, K. Kuca, D. Jun, and G. Kunesova
Bispyridinium Oximes As Antidotal Treatment of Cyclosarin Poisoning--In Vitro and In Vivo Testing
International Journal of Toxicology, November 1, 2005; 24(6): 399 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
V. Gersl, J. Bajgar, O. Krs, R. Hrdina, V. Palicka, and Y. Mazurova
Changes in cholinesterase activities after daunorubicin administration to rabbits
Human and Experimental Toxicology, October 1, 1996; 15(10): 834 - 838.
[Abstract] [PDF]


Advertisement