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Human & Experimental Toxicology
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Review : Neuropsychopathological changes by organophosphorus compounds — a review

P. Eyer

Walther-Straub-Institut für Pharmakologie und Toxikologie der Universität München, Nussbaumstrasse 26, D-80336 München, Germany

1 Available literature dealing with neuropsychopathologi cal changes after exposure to organophosphate insecti cides is reviewed.

2 Subacute neurological sequelae following acute organophosphate intoxication include the 'intermediate syndrome', probably a myopathy elicited by excess acetylcholine, and the 'organophosphate-induced delayed neuropathy' (OPIDN), which is caused by particularly neurotoxic organophosphates that inhibit neuropathy target esterase.

3 Long-term toxic effects affecting behaviour as well as mental and visual functions are occasionally observed after exposure to high doses of organophosphates with repeated acute, clinically significant intoxications.

4 The available data do not indicate that asymptomatic exposure to organophosphates is connected with an increasing risk of delayed or permanent neuro psychopathological effects.

Key Words: organophosphates • neuropsychopathological effects • pollution • OPIDN

Human & Experimental Toxicology, Vol. 14, No. 11, 857-864 (1995)
DOI: 10.1177/096032719501401101
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