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Human & Experimental Toxicology
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Glutathione Deficiency does not Elevate Susceptibility of Bacteria to the Mutagenicity of Chlorinated Humic Acids

G.A. Ubom

School of Biochemistry, The Unviersity of Birmingham, Edgbaston, Birmingham B15 2TT, UK

J.K. Chipman

School of Biochemistry, The Unviersity of Birmingham, Edgbaston, Birmingham B15 2TT, UK

M.H.B. Hayes

School of Chemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

1 Rat liver 9,000 g supernatant protected against the mutagenic effect of chlorinated hydrophilic macromolecular humic acids (CHMA) in Salmonella typhimurium strain TA100.

2 Protection against mutagenicity of CHMA was mediated by glutathione and was partially dependent on glutathione S-transferase activity.

3 In contrast to the above findings, CHMA showed lower mutagenicity in Salmonella typhimurium and Escherichia coli strains of bacteria that are deficient in glutathione compared to their mutagenicity in parental (glutathione-rich) bacterial strains.

4 Glutathione-deficient cells do not provide test systems with elevated sensitivity for the detection of mutagenic chlorinated humic substances.

Human & Experimental Toxicology, Vol. 13, No. 8, 558-562 (1994)
DOI: 10.1177/096032719401300809
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