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Inhaled tert-Butyl Acetate and its Metabolite tert-Butyl Alcohol Accumulate in the Blood during Exposure

Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Maybachstrasse 14-16, D-68169 Mannheim, Germany

K.J. Freundt

Institute of Pharmacology and Toxicology, Faculty of Clinical Medicine, University of Heidelberg, Maybachstrasse 14-16, D-68169 Mannheim, Germany

1 A continuous 5 h-exposure to approximately 440 ppm tert-butyl acetate in air (via a tracheal canule) resulted in continuously increasing concentrations of tert-butyl acetate and tert-butyl alcohol (metabolite of tert-butyl acetate) in the blood of rats.

2 This accumulation of tert-butyl acetate and tert-butyl alcohol was reproduced during a continuous exposure to about 900 ppm tert-butyl acetate in air over a period of 4 h and 15 min. After the inhalation approximately 50% of the blood level of tert-butyl acetate decreased within 45 min, but that of tert-butyl alcohol remained unchanged at a high level.

3 The accumulation of tert-butyl acetate and tert-butyl alcohol should be relevant for the health risk assessment at the workside.

Human & Experimental Toxicology, Vol. 13, No. 7, 478-480 (1994)
DOI: 10.1177/096032719401300705


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