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Effects on Operant Learning and Brain Acetylcholine Esterase Activity in Rats following Chronic Inorganic Arsenic Intake

Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India

T. Desiraju

Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India

1 Very young and adult Wistar rats were given As⁵⁺, 5 mg arsenic kg^-1 body weight day^-1 (sodium arsenate).

2 Operant learning was tested in a Skinner box at the end of exposure and, in the case of developing animals, also after a recovery period.

3 Acetylcholine esterase (AChE) activity was estimated in discrete brain regions of these animals.

4 The animals exposed to arsenic took longer to acquire the learned behaviour and to extinguish the operant. AChE activity was inhibited in some regions of the brain.

Human & Experimental Toxicology, Vol. 13, No. 5, 353-356 (1994)
DOI: 10.1177/096032719401300511


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