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Intravenous Pyridoxine in Acute Ethanol Intoxication

Accident and Emergency Department, Aberdeen Royal Infirmary, Aberdeen AB9 2ZB

I. Phair

Accident and Emergency Department, Leicester Royal Infirmary, Leicester LE1 5WW

F. O'Dwyer

Accident and Emergency Department, Leicester Royal Infirmary, Leicester LE1 5WW

J.A. Henry

Poisons Unit, Guy's Hospital, London, SE1 9RT, UK

Intravenous pyridoxine was evaluated as an agent for the reversal of ethanol-induced central nervous depression in a randomised double blind controlled study of 108 patients presenting with a clinical diagnosis of acute ethanol intoxication to two accident and emergency departments. Level of consciousness, measured by a modified Glasgow coma scale, showed no significant change after a single 1 g dose of intravenous pyridoxine when compared to controls given saline, The mean fall in blood alcohol concentration after one hour was 33 mg dl ^-1 (7.2 mmol l^-1) in both groups suggesting that pyridoxine has no antidotal action and no short term effect on the rate of metabolism of ethanol.

Human & Experimental Toxicology, Vol. 13, No. 5, 321-323 (1994)
DOI: 10.1177/096032719401300507


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