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Human & Experimental Toxicology
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Methaemoglobinaemia due to Amyl Nitrite Inhalation: A Case Report

Régine Machabert

Service de Pharmaco-Toxicovigilance et Centre Anti-Poisons, Hôpital E. Herriot, 69003 Lyon, France

François Testud

Service de Pharmaco-Toxicovigilance et Centre Anti-Poisons, Hôpital E. Herriot, 69003 Lyon, France

Jacques Descotes

Service de Pharmaco-Toxicovigilance et Centre Anti-Poisons, Hôpital E. Herriot, 69003 Lyon, France

Methaemoglobinaemia is a potential toxic effect of aliphatic nitrites which are increasingly abused by male homosexuals and drug addicts because of marked vasodilating properties ('poppers'). In most instances, severe complications were described following the ingestion of large quantities of amyl, butyl or isobutyl nitrites. A deficiency in NADHdependent haemoglobin reductase in some patients has been noted. This is the first report of symptomatic methaemoglobinaemia following the inhalation of amyl nitrite.

Human & Experimental Toxicology, Vol. 13, No. 5, 313-314 (1994)
DOI: 10.1177/096032719401300505
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